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Tuesday, 19 June 2018

WHAT IS TRAMADOL


This medication is used to help relieve moderate to moderately severe pain. Tramadol is similar to opioid (narcotic) analgesics. It works in the brain to change how your body feels and responds to pain.
Tramadol oral tablet is a prescription drug that’s available as an immediate-release and extended-release tablet. Tramadol also comes as an extended-release oral capsule. Immediate-release drugs are released into the body right away. Extended-release drugs are released into the body slowly over time.
Both tramadol oral tablets are also available as generic drugs. The immediate-release tablet is also available as the brand-name drug Ultram. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in all strengths or forms as the brand-name drug.

Why it’s used

Tramadol is used to treat moderate to severe pain.
Tramadol may be used as part of a combination therapy. This means you may need to take it with other medications.

How it works

Tramadol belongs to a class of drugs called opioid agonists. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.
Tramadol works by changing how your brain senses pain. Tramadol is similar to substances in your brain called endorphins. Endorphins bind to receptors (parts of cells that receive a certain substance). The receptors then decrease the pain messages that your body sends to your brain. Tramadol works in a similar way to decrease the amount of pain your brain thinks you’re having.


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Friday, 10 February 2017

TRAMADOL - Best Pain Killer




Best Pain Killer Pills for all types of Pain  is TRAMADOL

Tramadol is used to relieve moderate to moderately severe pain. Tramadol extended-release tablets and capsules are only used by people who are expected to need medication to relieve pain around-the-clock. Tramadol is in a class of medications called opiate (narcotic) analgesics. It works by changing the way the brain and nervous system respond to pain.

How should this medicine be used?

Tramadol comes as a tablet, an extended-release (long-acting) tablet, and an extended-release (long-acting) capsule to take by mouth. The regular tablet is taken usually with or without food every 4 to 6 hours as needed. The extended-release tablet and extended-release capsule should be taken once a day. Take the extended-release tablet and the extended-release capsule at about the same time of day every day. If you are taking the extended-release capsule, you may take it with or without food. If you are taking the extended-release tablet, you should either always take it with food or always take it without food. Take tramadol exactly as directed. Do not take more medication as a single dose or take more doses per day than prescribed by your doctor. Taking more tramadol than prescribed by your doctor or in a way that is not recommended may cause serious side effects or death.
Your doctor may start you on a low dose of tramadol and gradually increase the amount of medication you take, not more often than every 3 days if you are taking the regular tablets or orally disintegrating tablets or every 5 days if you are taking the extended-release tablets or extended-release capsules.

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Tramadol no Prescription is Really Available



  1. Tramadol is a strong painkiller. It’s used to treat moderate to severe pain, for example after an operation or a serious injury.
    It’s also used to treat long-standing pain when weaker painkillers no longer work.
    Tramadol is available only on prescription. It comes as tablets, capsules and liquid drops that you swallow. It can also be given by injection but this is usually only done in hospital.
  2. Key facts

    • Tramadol works by blocking pain signals from travelling along the nerves to the brain.
    • The most common side effects of tramadol are feeling sick and dizzy.
    • It's possible to become addicted to tramadol, but this is rare if you're taking it to relieve pain as advised by your doctor.
    • It's best not to drink alcohol with tramadol as you're more likely to get side effects like feeling sleepy.
    • Tramadol is also called by the brand names Invodol, Larapam, Mabron, Maneo, Marol, Maxitram, Oldaram, Tilodol, Tradorec, Tramquel, Tramulief, Zamadol, Zeridame and Zydol.
  3. Who can and can't take tramadol

    Tramadol can be taken by adults and children aged 12 and over.
    Tramadol is not suitable for some people. Tell your doctor or pharmacist before starting the medicine if you have:
    • had an allergic reaction to tramadol or any other medicines in the past
    • an illness which causes seizures
    • a head injury
    • an addiction to alcohol, strong painkillers or recreational drugs
    • breathing difficulties
    • kidney or liver problems
    • had a reaction to other strong painkillers in the past
  4. How and when to take it

    It's important to take tramadol as your doctor has asked you to.
    The dose can vary but you should not normally take more than 400mg a day.
    Tramadol doesn't usually upset your tummy, so you can take it with or without food.

    Different types of tramadol

    Tramadol comes as:
    • tablets
    • capsules
    • liquid drops (that you mix with water and swallow)
    • an injection

    Tramadol drops, injections and some tablets and capsules are fast-acting. They start to work within 30 to 60 minutes. They're used for pain that is expected to last for only a short time. You may be told to take fast-acting tramadol only when you need it for pain or on a regular basis. Always follow the instructions given to you by your doctor.
    Some tramadol tablets and capsules are slow-release. This means the tramadol is gradually released into your body over either 12 or 24 hours. This type of tramadol takes longer to start working but lasts longer. It's used for long-term pain.
    Your doctor will decide the right dose for you, depending on how sensitive you are to pain and how bad your pain is. Your dose may need to be changed several times to find what works best for you. In general, you will be prescribed the lowest dose that relieves your pain.

    How to take it

    Fast-acting tramadol comes as capsules, drops and 2 different tablets - soluble and dissolve-in-the-mouth tablets:
    • capsules: swallow each capsule whole with plenty of water
    • drops: mix the drops into a glass of water then drink the whole contents of the glass
    • soluble tablets: dissolve each tablet in 50ml (1/2 cup) of water and drink
    • dissolve-in-the-mouth tablets: make sure your hands are dry before handling the tablet. Take the tablet out of the blister pack and put it on your tongue. Suck the tablet, do not chew it. After it has melted, swallow or have a drink of water. You can also dissolve the tablet in a glass of water if you prefer.

    Slow-release tramadol comes as tablets and capsules. It's important to swallow slow-release tramadol tablets and capsules whole with a drink of water.

    Do not break, crush, chew or suck slow-release tablets and capsules. If you do, the slow-release system won't work and the whole dose might get into your body in one go. This could cause a potentially fatal overdose.

    How often will I take it?

    How often you take it depends on the type of tramadol that you have been prescribed:
    • fast-acting tablets and capsules - usually 3 to 4 times a day
    • drops - usually 3 to 4 times a day
    • slow-release tablets and capsules - usually 1 or 2 times a day

    If you're 65 and over, or you have liver or kidney problems, you may be asked by your doctor to take tramadol less often.
    You can take your tramadol at any time of day but try to take it at the same time every day and space your doses evenly. For example, if you take tramadol twice a day and have your first dose at 8am, take your second dose at 8pm.

    Side effects

    Like all medicines, tramadol can cause side effects although not everyone gets them. Talk to your doctor or pharmacist if the side effects listed below bother you or don’t go away.

    Very common side effects

    Very common side effects of tramadol happen in more than 1 in 10 people and include:
    • feeling sick
    • dizziness

    Common side effects

    Common side effects of tramadol happen in more than 1 in 100 people. They include:
    • headache
    • sleepiness
    • vomiting
    • constipation
    • dry mouth
    • sweating
    • low energy

    Serious side effects

    Serious side effects are rare. Tell your doctor straight away if you get:
    • heart problems
    • seizures (fits)
    • breathing difficulty or short shallow breathing
    • dizzy, tired and have low energy - these can be a sign of low blood pressure
    • hallucinations (seeing or hearing things that are not there)
    • confusion
    • very sleepy
    • trouble peeing or you can't pee at all
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What is Zopiclone ? INSOMNIA




Traded as Imovane, Zimovane, and Dopareel, Zopiclone is an effective medicine for the treatment of insomnia. A nonbenzodiazepine hypnotic agent, this medicine differs from benzodiazepine medicines and it is classified as cyclopyrrolone. Though Zopiclone USA has sight chemical structure changes but it works similar to benzodiazepine drugs. It enhances the production of GABA neurotransmitter in the brain. It also interferes with the re-absorption process of certain neurotransmitters and thus it shows promising effect in the treatment of insomnia. Moreover, the medicine also helps in treating intermittent sleep pattern. You can Buy Zopiclone Online in tablet and liquid form. The latter is favorable for people who find swallowing hard pills difficult. You can get the medicine with valid prescription.

How does Zopiclone USA work?

A non-benzodiazepine hypnotic, Zopiclone acts on the brain and the neurotransmitters secreted within the brain by the nerve cells. It increases the activity of GABA brain chemical or neurotransmitter. It is a chemical secretion which is used by the nerve cells to communicate amongst them. GABA has a reputation for calming the brain cells. The effects are sleep initiation, anxiety reduction, and muscle relaxation. Zopiclone for Sale helps in reducing the time taken to fall asleep during the night time. Moreover, it also lengthens your sleep time.

Important facts about Zopiclone

  • People above the age of 18 are eligible to Buy Zopiclone Online. It is available with a valid prescription.
  • The medicine is not recommended for people with severe breathing issues. If you are dealing with obstructive sleep apnea where the breathing stops for a few seconds while you are asleep, you must not take this medicine.
  • Do not take Zopiclone for Sale with alcohol or alcoholic beverages.
  • Take the dosage before hitting the bed. Ensure that you will get eight hours of uninterrupted sleep. Keep the distractions such as electronic devices away.
  • The effect of Zopiclone USA stays longer and thus you may feel a little sleepy the next day. Do not take the next dosage until the effect of first dose wears off.
  • The medicine leaves a metallic taste in the mouth. Some people have reported dry mouth after taking the medicine.
  • The medicine is habit forming and therefore it is suggested not to take Zopiclone USA for more than four weeks.

How long does it take to kick in?

Zopiclone pills are available in two strengths – 3.75mg and 7.5mg. The latter is the standard dosage which needs to be administered right before sleeping. It takes approximately 60 minutes to start working. The lower dosage of 3.75mg is generally prescribed to elderly patients of age 65 years and more. It is also given to people with kidney or liver issues.

How long does Zopiclone stay in your system?

The medicine stays in your body approximately for 12 hours. The medicine should not be consumed with alcohol as this makes a user very sleepy and sluggish. Further, this combination might cause some serious side effects as well. The half-life of the Zopiclone USA is about 5 hours.

Is Zopiclone habit-forming?

Yes it is. Therefore, it is suggested not to extend the treatment span for more than 4 weeks. Also, buy Zopiclone Online only when it is being prescribed to you. Do not self medicate with this drug.

Does Zopiclone affect memory?

You may experience memory loss when you are on Zopiclone USA tablets. However, it is not as serious as a short-term memory loss. However, studies have shown that the medicine is safer to use even with standard dosage of 7.5mg taken daily.



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how to get a TRAMADOL Online


Do you want a painkiller that you can use for moderate to severe pain? Then Tramadol is an excellent choice. This painkiller is so powerful that it is used to treat post-operative pain, pain caused by illnesses and other severe pain problems. Tramadol is a prescription medicine that you can buy only after obtaining medical prescription from a GP.   If you don’t have time to visit your doctor, then you can also shop here  online. In this case, you can order Tramadol without a prescription here in this website at ChronicPaincap.com

Doctors prescribe tramadol to treat moderate to severe pain in adults. Tramadol comes as a tablet, and as an extended-release tablet or capsule to treat around-the-clock pain. It's in a class of pain drugs called opiate narcotic analgesics, which work by changing the way your brain responds to pain.


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How Tramadol works ?


 Tramadol is an opioid medication that’s used to treat moderate to severe pain. Tramadol works by changing the way the brain and body perceive pain. Specifically, tramadol both inhibits serotonin and norepinephrine reuptake AND activates opiate receptors in the central nervous system to enhancing the inhibitory effects on pain transmission in the spinal cord.  How long tramadol lasts depends on immediate release (4-6 hours) vs. extended release versions (24 hours).

More here on how fast tramadol works, for how long, and what you can do to make tramadol work better. Your questions about tramadol are welcomed at the end.

How Does Tramadol Affect The Brain And Nervous System?

Experts still don’t know the exact reasons why or how tramadol causes pain relief. However, they do know that tramadol is an opium-derived synthetic substance that interacts with opiate receptors in the brain, helping to lessen the sensations of pain, treat withdrawal symptoms, and sometimes create feelings of euphoric pleasure. Further, tramadol has dual mechanisms of action which result in pain relief:

1. enhancement of serotonin and norepinephrine transmission

2. micro-opioid receptor activation

So given the function of tramadol, can you overdose on tramadol? Yes, it is possible to overdose on tramadol.  The recommended daily dose of tramadol is 450 mg per day.


How Does Tramadol Work In The Body?

Tramadol works in the body by first affecting the brain. Tramadol is a central nervous system depressant whose effects can result in:

dizziness
drowsiness
loss of consciousness
impaired coordination
pain relief
shallow breathing
slowed heart rate
nausea/vomiting
Some of these side effects can be dangerous and even life-threatening, but serious side effects normally only occur when tramadol is not taken as directed.

How Fast Does Tramadol Work

After oral administration, tramadol is rapidly and almost completely absorbed. Tramadol hits its peak blood plasma level an hour and a half after the drug is taken, at which point it takes full effect. Sometimes people will crush and snort tramadol powder from the tablets to try to get more immediate effects, but this is dangerous and can result in increased adverse effects, nasal infections, or overdose.

How Long Does Tramadol Work?

Tramadol has a half life of 6 hours. The immediate-release tramadol tablet will need to be taken every 4-6 hours for continuous pain relief, otherwise the effects will wear off. The extended-release tramadol tablet, used mainly to manage chronic pain, will last for 24 hours. This tablet is only taken once a day.



Does Tramadol Work For Everyone?

No, Tramadol is not right for everyone. In some people, tramadol can have serious side effects or cause an allergic reaction. Plus, tramadol is a habit-forming medication, so it’s not recommended for those with a history of drug or alcohol abuse.

If you experience problems while taking tramadol, you should talk to your doctor immediately about discontinuing the medication. There may be other medications you’re taking which interact with tramadol, so always check with your pharmacist before taking any new medications.



ETIZOLAM

Etizolam is a thienodiazepine which is chemically related to benzodiazepine (BDZ) drug class; it differs from BDZs in having a benzene ring replaced with a thiophene ring. It is an agonist at GABA-A receptors and possesses amnesic, anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties. Initially introduced in 1983 in Japan as treatment for neurological conditions such as anxiety and sleep disorders, etizolam is marketed in Japan, Italy and India. It is not approved for use by FDA in the US; however it remains unscheduled in several states and is legal for research purposes.



Indicated for the treatment of Generalized Anxiety disorder with Depression, Panic disorder and insomnia. Major adverse effects include drowsiness, sedation, muscle weakness and incoordination, fainting, headache, confusion, depression, slurred speech, visual disturbances and changes in libido and tremor [L883]. Flumazenil is a competitive antagonist of GABA-A receptors and can be also used to reverse the effect of etizolam overdosage. Etizolam demonstrates no effects on fertility, development and teratogenicity [L884]. LD50 values of etizolam when delivered orally, intraperitoneally, and subcutaneously are 3509mg/kg, 825mg/kg, and >5000mg/kg in rats, respectively, and 3070mg/kg, 783mg/kg and 5000mg/kg in mice, respectively [MSDS].





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Buy Tramadol for pain relief



What is Tramadol used for?

Strong opioids (sometimes called opiates) are medicines used to treat severe pain. Tramadol is a type of strong opioid. It works on your nervous system and brain to reduce the way you feel pain.

There are many different forms, strengths and brands of tramadol. Some forms and brands of tramadol start working quickly to ease pain. Others release the tramadol they contain more slowly over several hours to provide a constant and more-even pain control - these are called 'modified-release' and often have 'XL', 'SR' or '24hr' after their brand name.


How do I take fast-acting tramadol?

  • Tramadol capsules, soluble tablets, oral drops and orodispersible tablets start to work quickly and their effects wear off after a few hours. Fast-acting forms such as these may be prescribed to take only when needed to relieve pain, or on a regular basis, depending on the cause of your pain.
  • The usual dose for a healthy adult is 50mg to 100mg every four to six hours, up to a maximum of 400mg in 24 hours, but always follow the instructions given by your doctor.
  • Tramadol soluble tablets should be dissolved in at least 50ml water before taking.
  • Tramadol orodispersible tablets should be sucked and then swallowed. Alternatively they can be dispersed in half a glass of water before taking.

How do I take slow-release tramadol?

  • Tramadol modified-release capsules and modified-release tablets are designed to release tramadol slowly and continuously over 12 or 24 hours as the medicine passes through the gut. This provides steady blood levels of the medicine over the day and prolonged pain relief. These forms of tramadol are taken on a regular basis to control ongoing pain.
  • You may be given a 12-hourly or 24-hourly formulation and it's important to know which you have been prescribed.
  • Brands that should be taken twice a day at 12 hour intervals (eg 8am and 8pm) include: Invodol SR, Mabron, Maneo, Marol, Maxitram SR, Oldaram, Tilodol SR, Tramquel SR, Tramulief SR, Zamadol SR, Zeridame SR and Zydol SR.
  • Brands that should be taken once a day at the same time each day (every 24 hours) include: Tradorec XL, Zamadol 24hr and Zydol XL.
 Tramadol modified-release capsules and tablets must be swallowed whole. Do not break, crush or chew them, as this will cause the whole dose to be rapidly absorbed into your body, which could result in an overdose.
  • Talk to your doctor if you have trouble swallowing, because some brands of modified-release capsules can be opened so you can swallow just the contents without chewing. Check the leaflet provided with your capsules to see if this is the case.

How long should I take tramadol for?

Keep taking tramadol for as long as your doctor tells you to. If you've been taking it for long periods of time you shouldn't stop taking it suddenly - your dose should be reduced gradually. Always follow your doctor's instructions.

What should I do if I miss a tramadol dose?

This depends on the form of tramadol you're taking and how late you are taking the dose. Read the leaflet provided with your medicine to find out what to do, or call your doctor or pharmacist for advice. Never take a double dose of tramadol to make up for a missed dose.

What if I take too much tramadol?

If you accidentally take more than your prescribed tramadol dose, or if someone has taken a tramadol overdose, you should contact your doctor immediately, or go to the accident and emergency department of your nearest hospital. Take the container with you, even if it's empty.


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